HPV Vaccine: Scientific Studies
Updated Sept 2016
compiled by Norma Erickson, SaneVax
The following are links to data on various adverse events after HPV vaccines from published scientific papers:
·
Current Safety Concerns w/HPV vax: Cluster
Analysis/Vigibase, author from Uppsala Monitoring Centre/WHO
·
Pancreatitis
following human papillomavirus vaccination, (behind paywall,
published in The Medical Journal of
Australia, 2008
·
Pancreatitis after human papillomavirus
vaccination: a matter of molecular mimicry. Published in Immunologic Research, Shoenfeld et al
·
Severe somatoform and dysautonomic syndromes
after HPV vaccination: case series and review of literature Palmieri et al., Immunologic
Research 09 Aug 2016
·
Vaccinations and secondary immune thrombocytopenia with antiphospholipid
antibodies by human papillomavirus vaccine.Bizjak M, et al.
Semin Hematol. 2016.
·
Autoimmune/auto-inflammatory
syndrome induced by adjuvants (ASIA) after quadrivalent human papillomavirus
vaccination in Colombians: a call for personalised medicine. Study
conducted in Bogota, Colombia
·
On the relationship between
HPV vaccine and autoimune diseases (Again, behind a paywall but worth
investigating as it identifies 736 case reports of autoimmune diseases after
HPV vaccines.ALSO, the concluding statement includes: ”The decision to
vaccinate with HPV vaccine is a personal decision, not one that must be made
for public health. HPV is not a lethal disease in 95% of the infections; and
the other 5% are detectable and treatable in in the precancerous stage.”)
·
Hypothesis: HPV
vaccination syndrome – small fiber neuropathy and dysautonomie could be its
underlying pathogenesis
·
Japan:
Orthomolecular Treatment for Adverse Effects of HPV vaccine (also lists
common effects)
·
Detection of human
papillomavirus L1 gene DNA fragments in postmortem samples after GardasilSin Hang Lee, MD
These are scientific papers which may assist, but do not specifically tie HPV vaccines to adverse events:
·
Insight into the
cellular fate and toxicity of aluminium adjuvants used in clinically approved
human vaccinations Chris Exley, et al
·
Evidence
of type replacement? IPAK (Institute for Pure and Applied Knowledge)
·
Shift in HPV type prevalence
post-vaccination Fischer et al July 2016
·
Molecular variants
of HPV 16 from 4 continents suggest ancient pandemic spread of the virus and
its coevolution with humankind (published in 1992) One has to wonder why humans
still exist if this virus is so dangerous. Also notable that this was published
prior to the development of HPV vaccines.
·
A summary of the
post-licensure surveillance initiatives for Gardasil Silgard Behind a
paywall, but worth examining.
·
Review:
Immunigenicity, and Efficacy of HPV vaccines in Low and Middle Income Countries
(Note: the vast majority of subjects were only followed up on formally for 7
days post-vaccination – remainder of follow-up was on ’unsolicited’ events.
This most likely means it was up to the recipients to report, if they were so
inclined. The other problem is the ’placebo’ used in the vast majority of these
trials was not an inert solution.)
·
HPV
vaccines and cancer prevention, science versus activism Tomljenovic/Shaw et
al
·
HPV
Vaccines as an option for prevention of cervical cancer: How effective and
Safe? Tomljenovic/Shaw/Spinosa
·
HPV
vaccine policy and evidence-based medicine: Are they at odds?
Tomljenovic/Shaw
·
Prophylactic
HPV Vaccines: Current knowledge of Impact on Gynecological Premalignancies
Diane Harper/Karen Williams
Additional medical/scientific presentations around the globe:
Medical and Scientific Evidence Submitted in Japan 2014:
Dr.
Authier (data presented at the public hearing, at the meeting with the Senators
and at news conferences)
1)
Aluminum salts used as adjuvants in HPV vaccines can cause myalgia,
chronic fatigue syndrome, cognitive impairment, overt autoimmune disease,
multiple sclerosis, DM, thyroiditis…)
2)
Macrophagic myofasciitis, biopsy proven, is significantly associated
with above conditions.
3)
Alum particles can be transported by monocyte-lineage cells to lymph
nodes, blood and spleen, and penetrate the blood brain barrier with potential
damages to nerve tissues.
4)
Aluminum salts are poorly biodegradable as adjuvant in HPV vaccines.
Dr.
Hajjar (data presented at the meeting with the Senators and at news
conferences, and admitted to public hearing through Dr. Sin Hang Lee)
1)
Dr. Hajjar reported the case of a 16-year-old girl who suffered an
acute-onset and permanent bilateral visual loss and a transient left
hemiparesis following Gardasil vaccination.
2)
Tumefactive demyelinating lesions and chiasmal neuritis as part of a
presentation of acute demyelinating encephalomyelitis were documented by MRI
imaging studies.
3)
A brain biopsy was performed on this case to confirm that there was a
perivascular infiltration of lymphocytes and macrophages with focal
demyelination in the brain tissue, characteristic of the histopathological
changes in acute demyelinating (or disseminated) encephalomyelitis as
complication of vaccination.
Dr.
Tomljenovic (data presented at the meeting with the Senators and news
conferences)
1)
Post-mortem brain tissue specimens from two young women who suffered from
cerebral vasculitis-type symptoms following vaccination with the HPV vaccine
Gardasil were analyzed by IHC for various immuno-inflammatory markers.
2)
Gardasil-vaccinated cases showed positive immuno-reactivity for HPV-16L1
antigen in cells within cerebral vessels, with some HPV-16L1 – positive cells
adhering to the walls of these vessels and some infiltrating the brain
parenchyma. No such pattern of staining was observed with the anti-HPV-18L1
anti-HPV-11L1 antibody in any of the Gardasil-vaccinated cases. Control cases
were negative.
3)
Conclusions: The presence of foreign antigenic material in the central
nervous system can trigger adverse inflammatory and immune-mediated
manifestations. Normally, vaccine antigens are not expected to cross the
blood-brain barrier. The finding of HPV-16L1 intra and perivascular
immuno-positive cells in the brains of these two cases suffering unexpected and
sudden death following Gardasil vaccination is thus of concern.
Dr.
Lee (data presented at the public hearing, at the meeting with the Senators and
at news conferences)
1)
Gardasil contains residual HPV L1 gene rDNA fragments, firmly bound to
the AAHS adjuvant by ligand exchange through the phosphate backbone of the DNA
molecule in non-B conformation – a new chemical inadvertently created in the
vaccine manufacturing process.
2)
It is well known that aluminum nanoparticles can transfect foreign,
bacterial or viral DNA into human cells, especially macrophages, and
macrophages can cross the blood brain barrier.
3)
It is well known that activated macrophages, highly immune-stimulated by
free bacterial or viral DNA, can produce and release a variety of cytokines,
including tumor necrosis factor which is a myocardial depressant and can cause
acute inflammation. Human macrophages recognize HPV DNA as a viral DNA (foreign
invader), not the DNA from the human host’s own body, and react in a high alert
state- a highly augmented reaction which may be very harmful in certain
genetically predisposed young girls. We cannot predict which girls will react
violently in their heart and in their brain as a result of these activated
macrophage activities.
4)
HPV 16 L1 gene DNA in non-B conformation was found in the
post-mortem blood and spleen tissue obtained at autopsy of such a sudden
unexpected death without obvious cause of death 6 months after Gardasil
vaccination. No scientists at the public hearing believe that psychosomatic reactions
can cause such death and inflammation of the brain in these HPV-vaccinated
girls. Therefore, more research must be performed on the potential toxicity of
this vaccine.
Evidence presented in France 2014:
Dr. Sin
Hang Lee, described
his Gardasil research to date, stating:
I have tested 16 samples of the HPV vaccine
Gardasil, each of different lot number, from 9 countries, and found that they
all contained fragments of residual HPV DNA, namely viral DNA which was used to
manufacture the HPV vaccine antigens by a genetic engineering technology.
Furthermore, the viral DNA fragments in a non-B
conformation were firmly bound to the aluminum adjuvant in the vaccine by
ligand exchange, an inadvertently created chemical compound containing viral
DNA which can be transfected into the host cells, namely the human phagocytes
and macrophages.
Based on established research, this viral DNA
can activate the innate immune system of the macrophages to generate and
release cytokines, including tumor necrosis factor in the vaccine recipients.
In certain genetically predisposed individuals,
the level of tumor necrosis factor may be high enough to cause hypotension,
fainting, tachycardia, unexpected sudden death and acute disseminated
encephalomyelitis, namely adverse reactions which have been documented
following Gardasil vaccination.
Professor
Belec, head of
the Laboratory of Virology, Hospital European Georges Pompidou, confirmed the
work of Dr. Lee on Gardasil, stating:
We found residual viral DNA fragments, which
should not be there. This is true residual contamination, probably related to
the manufacturing process. Between 200 and 400 fragments of residual DNA in
Gardasil. This is not normal.
What is the meaning? I do not know. Dr. Lee
showed us in his work that this fragment was associated with aluminum
hydroxyphosphate. This is not any normal way.
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